Idiopathic Inflammatory Myopathies: A Review of Immunopathological Features and Current Models of Pathogenesis

@inproceedings{Cappelletti2011IdiopathicIM,
  title={Idiopathic Inflammatory Myopathies: A Review of Immunopathological Features and Current Models of Pathogenesis},
  author={Cristina Cappelletti and Lucia Ovidia Morandi and Marina Mora and Franco Salerno and Paolo Confalonieri and Renato Mantegazza and Pia Bernasconi},
  year={2011}
}
The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of chronic systemic disorders characterized by muscle inflammation and progressive muscle weakness. The major clinical variants are dermatomyositis (DM) including a distinct juvenile (JDM) subtype, polymyositis (PM), and inclusion body myositis (IBM) (Engel & Hohlfeld, 2004). IBM is divided into sporadic IBM (sIBM), the most common muscle disease starting after age 50 years, occurring mainly in men and leading to severe… 

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Clinico pathological study of adult dermatomyositis: Importance of muscle histology in the diagnosis
TLDR
Histological features are important for the diagnosis of DM, and reliance on PFA for diagnosis of definite DM underestimates the true frequency of DM.

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