Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

@article{Beutler1985IdentityOT,
  title={Identity of tumour necrosis factor and the macrophage-secreted factor cachectin},
  author={B. Beutler and Douglas Greenwald and J. Hulmes and M. Chang and Y. Pan and J. Mathison and R. Ulevitch and A. Cerami},
  journal={Nature},
  year={1985},
  volume={316},
  pages={552-554}
}
In mammals, several well-defined metabolic changes occur during infection, many of which are attributable to products of the reticuloendothelial system1–3. Among these changes, a hypertrigly-ceridaemic state is frequently evident4–9, resulting from defective triglyceride clearance, caused by systemic suppression of the enzyme lipoprotein lipase (LPL)9. We have found previously that macrophages secrete the hormone cachectin, which specifically suppresses LPL activity in cultured adipocytes (3T3… Expand
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