Identity of the abnormal F-group chromosome associated with polycythaemia vera

Abstract

A technique for the identification of individual chromosomes has been applied to bone marrow cells from 4 patients with polycythaemia vera. These patients were already known to have the abnormal F-group chromosomes which occur in about 20% of cases of this disease. In each individual the particular chromosome involved was found to be a number 20, from which some material had been deleted, probably from the long arm. Eine Technik für die Identifikation einzelner Chromosomen wurde auf Knochenmarkzellen von 4 Patienten mit Polycythaemia Vera angewandt. Von diesen Patienten wußte man bereits, daß sie die abnormen F-Chromosomen besitzen, die in ungefähr 20% der Fälle dieser Krankheit vorkommen. Bei allen 4 Patienten stellete sich heraus, daß das spezielle Chromosom die Nr. 20 hat; es bestand jeweils eine Deletion, wahrscheinlich des langen Armes.

DOI: 10.1007/BF00273302

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@article{Reeves1972IdentityOT, title={Identity of the abnormal F-group chromosome associated with polycythaemia vera}, author={Benjamin Reeves and David Lobb and Sylvia D. Lawler}, journal={Humangenetik}, year={1972}, volume={14}, pages={159-161} }