Identity of cells that imprint H–2-restricted T-cell specificity in the thymus

@article{Lo1986IdentityOC,
  title={Identity of cells that imprint H–2-restricted T-cell specificity in the thymus},
  author={David Lo and Jonathan Sprent},
  journal={Nature},
  year={1986},
  volume={319},
  pages={672-675}
}
The thymus has two important roles in controlling the specificity of T lymphocytes. First, T cells differentiating in the thymus are rendered tolerant of ‘self’ antigens, particularly antigens encoded by the major histocompatibility complex, the H–2 complex in mice1. Second, the thymus imbues T cells with the property of H–2-restricted recognition of antigen, that is, the capacity of T cells to react with foreign antigens presented in association with self H–2 gene products2,3. Until recently… CONTINUE READING