Identity of borrelidin with treponemycin.

  title={Identity of borrelidin with treponemycin.},
  author={Hubert Maehr and R. H. Evans},
  journal={The Journal of antibiotics},
  volume={40 10},
has been described as a novel antibiotic, produced by Streptomyces activity against Treponema hyodysenteriae ester a nitrile hydroxyl 
Borrelidin - An Antiangiogenic Compound
An effort in the direction of isolating an antibiotic capable of acting on clinical resistant strains of infectious organisms, which is isolated from Streptomyces californicus.
Anti-Tuberculous Activity of Treponemycin Produced by a Streptomyces Strain MS-6-6 Isolated from Saudi Arabia
A Streptomyces strain MS-6-6 with promising anti-tuberculous activity was isolated from soil samples in Saudi Arabia and identified as treponemycin (TP), which showed broad spectrum of activity against the Gram positive, Gram negative strains, and Candida albicans.
Truncated borrelidin analogues: synthesis by sequential cross metathesis/olefination for the southern fragment and biological evaluation.
The construction of novel borrelidin analogues is reported in which the northern fragment is truncated to a simple hydroxyundecanecarboxylate and the original cyclopentanecarboxylic acid in the
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation †
A pathway is proposed for the formation of the nitrile moiety during borrelidin biosynthesis, suggesting that 12‐desnitrile‐12‐methyl‐borrelid in is a competent biosynthetic intermediate, whereas the carboxylated derivative is a shunt metabolite.
Bioprocess Development for the Production of Bioactive Compounds from Actinomycetes Isolates from Al- Khurmah Governorate
The purified antimicrobial agent was suggestive of being belonging to 18 membered polyketide macrolide antibiotic group (Borrelidin or Treponemycin antibiotic) produced by Streptomyces rimosus, KH-1223-55.
Total synthesis of (-)-borrelidin.
The total synthesis of borrelidin has been achieved. The best feature of our synthetic route is SmI(2)-mediated intramolecular Reformatsky-type reaction for macrocyclization after esterification
Formal synthesis of the anti-angiogenic polyketide (-)-borrelidin under asymmetric catalytic control.
This modular approach takes optimal benefit of asymmetric catalysis and permits the synthesis of analogues; in addition, the high yields and selectivities obtained eliminate the need for separation of stereoisomers.
Chemoenzymatic Synthesis of the C3–C11‐Fragment of Borrelidin
The ex-chiral pool synthesis of the Theodorakis C3–C11 fragment of borrelidin (1) by a chemoenzymatic approach in nine steps and 12 % overall yield starting from enantiopure methyl-branched preen
Bioassay- and metabolomics-guided screening of bioactive soil actinomycetes from the ancient city of Ihnasia, Egypt
The study aims to utilise bioassay- and metabolomics-guided tools that included dereplication study and multivariate analysis of the NMR and mass spectral data of microbial extracts to assist the selection of isolates for scaling-up the production of antimicrobial natural products.


Isolation of Vivomycin and Borrelidin, Two Antibiotics with Anti-Viral Activity, from a Species of Streptomyces (C2989)
Isolation of Vivomycin and Borrelidin, Two Antibiotics with Anti-Viral Activity, from a Species of Streptomyces (C2989) shows positive results for isolation and anti-viral activity.
Treponemycin, a nitrile antibiotic active against Treponema hyodysenteriae
The antibiotics isolated from soil samples collected from the fields around Lewiston, Idaho showed inhibitory activity against several species of bacteria, especially Treponema hyodysenteriae, the causative agent of swine dysentery, and may have value as a swine Dysentery therapeutic.
Goldberg: Borrelidin, a antibiotic with antiborrelia activity and penicillin enhancement properties
  • Arch. Biochem. Biophys
  • 1949