Identity and function of a cardiac mitochondrial small conductance Ca2+-activated K+ channel splice variant.

@article{Yang2017IdentityAF,
  title={Identity and function of a cardiac mitochondrial small conductance Ca2+-activated K+ channel splice variant.},
  author={Meiying Yang and Amadou K. S. Camara and Mohammed Aldakkak and Wai-Meng Kwok and David F. Stowe},
  journal={Biochimica et biophysica acta. Bioenergetics},
  year={2017},
  volume={1858 6},
  pages={
          442-458
        }
}
We provide evidence for location and function of a small conductance, Ca2+-activated K+ (SKCa) channel isoform 3 (SK3) in mitochondria (m) of guinea pig, rat and human ventricular myocytes. SKCa agonists protected isolated hearts and mitochondria against ischemia/reperfusion (IR) injury; SKCa antagonists worsened IR injury. Intravenous infusion of a SKCa channel agonist/antagonist, respectively, in intact rats was effective in reducing/enhancing regional infarct size induced by coronary artery… CONTINUE READING

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