Identifying weak signals in the presence of noise: a new method of locating potential ligand contact residues in immunoglobulin-related molecules.

@article{GexFabry1989IdentifyingWS,
  title={Identifying weak signals in the presence of noise: a new method of locating potential ligand contact residues in immunoglobulin-related molecules.},
  author={Marianne Gex-Fabry and Fernanda Marchetti and Kohjiro Nakata and Charles DeLisi},
  journal={Molecular immunology},
  year={1989},
  volume={26 12},
  pages={
          1169-78
        }
}
We develop and apply a new method for estimating the locations of hypervariable residues in immunoglobulin-related molecules. The method differs from the standard introduced by Wu and Kabat in two essential ways: (1) we take explicit account of the type of substitution at a given position, rather than just the total number of substitutions, and (2) we use an explicit statistical decision criterion for classifying a site into either the complementarity determining or framework category… CONTINUE READING
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