Identifying transcription factor functions and targets by phenotypic activation.

  title={Identifying transcription factor functions and targets by phenotypic activation.},
  author={Gordon Chua and Quaid Morris and Richelle Sopko and Mark D. Robinson and Owen W. Ryan and Esther T. Chan and Brendan J. Frey and Brenda J. Andrews and Charles Boone and Timothy R. Hughes},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 32},
Mapping transcriptional regulatory networks is difficult because many transcription factors (TFs) are activated only under specific conditions. We describe a generic strategy for identifying genes and pathways induced by individual TFs that does not require knowledge of their normal activation cues. Microarray analysis of 55 yeast TFs that caused a growth phenotype when overexpressed showed that the majority caused increased transcript levels of genes in specific physiological categories… CONTINUE READING
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