Identifying therapeutic targets in a combined EGFR-TGFβR signalling cascade using a multiscale agent-based cancer model.

@article{Wang2012IdentifyingTT,
  title={Identifying therapeutic targets in a combined EGFR-TGFβR signalling cascade using a multiscale agent-based cancer model.},
  author={Zhihui Wang and Veronika Bordas and Jonathan Sagotsky and Thomas S. Deisboeck},
  journal={Mathematical medicine and biology : a journal of the IMA},
  year={2012},
  volume={29 1},
  pages={95-108}
}
Applying a previously developed non-small cell lung cancer model, we assess 'cross-scale' the therapeutic efficacy of targeting a variety of molecular components of the epidermal growth factor receptor (EGFR) signalling pathway. Simulation of therapeutic inhibition and amplification allows for the ranking of the implemented downstream EGFR signalling… CONTINUE READING