Identifying the role of Wilms tumor 1 associated protein in cancer prediction using integrative genomic analyses.

  title={Identifying the role of Wilms tumor 1 associated protein in cancer prediction using integrative genomic analyses.},
  author={Li-Sheng Wu and Jia-Yi Qian and Minghai Wang and Haiwei Yang},
  journal={Molecular medicine reports},
  volume={14 3},
The Wilms tumor suppressor, WT1 was first identified due to its essential role in the normal development of the human genitourinary system. Wilms tumor 1 associated protein (WTAP) was subsequently revealed to interact with WT1 using yeast two-hybrid screening. The present study identified 44 complete WTAP genes in the genomes of vertebrates, including fish, amphibians, birds and mammals. The vertebrate WTAP proteins clustered into the primate, rodent and teleost lineages using phylogenetic tree… 

Figures and Tables from this paper

Upregulated WTAP expression in colorectal cancer correlates with tumor site and differentiation

It is suggested that WTAP expression is upregulated in CRC, highly expressed in left colon cancer and negatively correlated with tumor differentiation, as well as depth of tumor invasion.

Gene Signatures and Prognostic Values of m6A RNA Methylation Regulators in Ovarian Cancer

The findings demonstrate the significance of high-frequency genetic alterations of m6A RNA methylation regulators and WTAP’s poor prognosis value in OC, and will be vital in guiding development of novel treatment therapies.

Upregulated WTAP expression appears to both promote breast cancer growth and inhibit lymph node metastasis

It is suggested that WTAP expression is upregulated in breast cancer and appears to both promote tumor growth and inhibit lymph node metastasis.

METTL3 regulates m6A in endometrioid epithelial ovarian cancer independently of METTl14 and WTAP

The high expressed METTL3 indicated poor malignancy and survival of EEOC via modulating the aberrant m6A RNA methylation.

Functions and mechanisms of N6-methyladenosine in prostate cancer

A review of the recent findings on m6A regulation and its functions and mechanisms in cells, focusing on the various functional proteins operating within m 6A in PCa cells found the potential clinical value of exploitingm6A modification as an early diagnostic marker in PCA diagnosis and therapeutics.

N6-methyladenosine as a biological and clinical determinant in colorectal cancer: progression and future direction

M6A regulators and m6A-related RNAs may become promising biomarkers, prognosis predictors as well as therapeutic targets in CRC and the potential of m 6A in clinical translation is discussed.

DNA methylation analysis of selected genes for the detection of early-stage lung cancer using circulating cell-free DNA.

Quantitative detection of DNA methylation in plasma is a potential method for early diagnosis of lung cancer.

Importance of N6-methyladenosine RNA modification in lung cancer (Review)

The current review summarized the biological functions of m6A modification and considers the potential roles of m5-methyladenosine regulators in the occurrence and development of lung cancer.

The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms

This paper focuses on WTAP, a component of the m6A methyltransferase complex, and introduces its structure, localization, and physiological functions, and describes its roles and mechanisms in cancer.

An integrated genome-wide multi-omics analysis of gene expression dynamics in the preimplantation mouse embryo

Protein abundance profiles were weakly correlated with those of their cognate mRNAs and concordance increased towards morula and blastocyst, hinting at a more direct coupling of proteins with transcripts at these stages, in agreement with the increase in free ribosome abundance.



Identification of WTAP, a novel Wilms' tumour 1-associating protein.

The identification of a novel human WT1-associating protein, WTAP, which was isolated using the yeast two-hybrid system and found to be >90% conserved at the nucleotide and protein levels.

Expression and roles of Wilms' tumor 1‐associating protein in glioblastoma

It is shown for the first time that WTAP is overexpressed in glioblastoma and the activity of epidermal growth factor receptor can be regulated by WTAP, which reveals a novel function of WTAP and suggests its clinical application.

Role of the Wilms' tumor 1 gene in the aberrant biological behavior of leukemic cells and the related mechanisms.

It is demonstrated that the WT1 gene was commonly expressed in leukemic cell lines apart from U937 cells, and one important mechanism is regulation of the Wnt/β-catenin pathway.

Identification of Wilms' Tumor 1-associating Protein Complex and Its Role in Alternative Splicing and the Cell Cycle*

Findings show that the WTAP complex is a novel component of the RNA processing machinery, implying an important role in both posttranscriptional control and cell cycle regulation.

Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA

Findings establish WTAP as an essential factor for the stabilization of cyclin A2 mRNA, thereby regulating G2/M cell-cycle transition and establishing the role of siRNA in this role.

An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1

It is shown that WT1 blocked the ability of Wnt8 to induce a secondary body axis during Xenopus embryonic development and interference with Wnt signaling represents an important mode of its action relevant to the suppression of tumor growth and guidance of development.

Identification of differentially expressed genes and their subpathways in recurrent versus primary bone giant cell tumors.

This study identified differentially expressed genes and their subpathways in recurrent GCT, which may serve as potential biomarkers for the prediction of GCT recurrence.

iTRAQ-based quantitative proteomic analysis of cervical cancer.

The notion that suppressing the expression of G6PD may be a promising strategy in developing novel cancer therapeutic drugs is supported, which complemented the understanding of cervical cancer progression.

Integrative genomic analyses of a novel cytokine, interleukin-34 and its potential role in cancer prediction

It was found that the association between the expression of IL-34 and cancer prognosis varied in different types of cancer, even in the same types ofcancer from different databases, which suggests that the function ofIL-34 in these tumors may be multidimensional.