Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-γ receptor subunit 1 (IFNGR1).

@article{Lee2013IdentifyingTI,
  title={Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-γ receptor subunit 1 (IFNGR1).},
  author={Sang Hun Lee and Javier A Carrero and Ravindra Uppaluri and J Michael White and Jessica M. Archambault and Koon Siew Lai and Szeman Ruby Chan and Kathleen C. F. Sheehan and Emil R Unanue and Robert D Schreiber},
  journal={Journal of immunology},
  year={2013},
  volume={191 8},
  pages={4223-34}
}
Although IFN-γ is required for resolution of Listeria monocytogenes infection, the identities of the IFN-γ-responsive cells that initiate the process remain unclear. We addressed this question using novel mice with conditional loss of IFN-γR (IFNGR1). Itgax-cre(+)Ifngr1(f/f) mice with selective IFN-γ unresponsiveness in CD8α(+) dendritic cells displayed increased susceptibility to infection. This phenotype was due to the inability of IFN-γ-unresponsive CD8α(+) dendritic cells to produce the… CONTINUE READING

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