Identifying the important structural elements of brominated furanones for inhibiting biofilm formation by Escherichia coli.

@article{Han2008IdentifyingTI,
  title={Identifying the important structural elements of brominated furanones for inhibiting biofilm formation by Escherichia coli.},
  author={Yongbin Han and Shuyu Hou and Karen A Simon and Dacheng Ren and Y S Luk},
  journal={Bioorganic & medicinal chemistry letters},
  year={2008},
  volume={18 3},
  pages={1006-10}
}
A collection of structurally closely related furanones was synthesized to identify the most important structural elements in brominated furanones for inhibiting the formation of bacterial biofilms. The results suggest that a conjugated exocyclic vinyl bromide on the furanone ring is the most important structural element for the non-toxic but inhibition activity for Escherichia coli biofilm formation. Furanones bearing monosubstituted bromide groups on saturated carbons were found to have a… CONTINUE READING