Identifying the fundamental units of bacterial diversity: a paradigm shift to incorporate ecology into bacterial systematics.

@article{Koeppel2008IdentifyingTF,
  title={Identifying the fundamental units of bacterial diversity: a paradigm shift to incorporate ecology into bacterial systematics.},
  author={Alexander F. Koeppel and Elizabeth B. Perry and Johannes Sikorski and Danny Krizanc and Andrew Warner and David M. Ward and Alejandro P. Rooney and Evelyne Brambilla and Nora Connor and Rodney Mark Ratcliff and Eviatar Nevo and Frederick Cohan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 7},
  pages={2504-9}
}
The central questions of bacterial ecology and evolution require a method to consistently demarcate, from the vast and diverse set of bacterial cells within a natural community, the groups playing ecologically distinct roles (ecotypes). Because of a lack of theory-based guidelines, current methods in bacterial systematics fail to divide the bacterial domain of life into meaningful units of ecology and evolution. We introduce a sequence-based approach ("ecotype simulation") to model the… CONTINUE READING

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