Identifying target genes regulated downstream of Cdx2 by microarray analysis.

@article{Uesaka2004IdentifyingTG,
  title={Identifying target genes regulated downstream of Cdx2 by microarray analysis.},
  author={Toshihiro Uesaka and Noriko Kageyama and Hiromitsu Watanabe},
  journal={Journal of molecular biology},
  year={2004},
  volume={337 3},
  pages={
          647-60
        }
}
The caudal-related homeobox transcription factor (Cdx2) plays an important role in intestinal development, differentiation, and homeostasis. However, only a limited number of Cdx2-regulated target genes have been elucidated. To delineate the molecular mechanism regulated downstream of Cdx2, we aimed to define Cdx2-regulated genes. We engineered a rat intestinal epithelial cell line, IEC-6, with minimal endogenous Cdx2 expression to express exogenous Cdx2. The gene expression patterns for Cdx2… Expand
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