Identifying sensitive windows for prenatal particulate air pollution exposure and mitochondrial DNA content in cord blood.

@article{Rosa2017IdentifyingSW,
  title={Identifying sensitive windows for prenatal particulate air pollution exposure and mitochondrial DNA content in cord blood.},
  author={Maria Jos{\'e} Alvarez Rosa and Allan C. Just and Marco S{\'a}nchez Guerra and Itai Kloog and Hsiao-Hsien Leon Hsu and Kasey J M Brennan and Adriana Mercado Garc{\'i}a and Brent A. Coull and Rosalind J Wright and Martha Mar{\'i}a T{\'e}llez Rojo and Andrea A. Baccarelli and Robert O. Wright},
  journal={Environment international},
  year={2017},
  volume={98},
  pages={
          198-203
        }
}
INTRODUCTION Changes in mitochondrial DNA (mtDNA) can serve as a marker of cumulative oxidative stress (OS) due to the mitochondria's unique genome and relative lack of repair systems. In utero particulate matter ≤2.5μm (PM2.5) exposure can enhance oxidative stress. Our objective was to identify sensitive windows to predict mtDNA damage experienced in the prenatal period due to PM2.5 exposure using mtDNA content measured in cord blood. MATERIAL AND METHODS Women affiliated with the Mexican… CONTINUE READING
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