Identifying selective inhibitors against the human cytosolic sialidase NEU2 by substrate specificity studies.

Abstract

Aberrant expression of human sialidases has been shown to associate with various pathological conditions. Despite the effort in the sialidase inhibitor design, less attention has been paid to designing specific inhibitors against human sialidases and characterizing the substrate specificity of different sialidases regarding diverse terminal sialic acid… (More)
DOI: 10.1039/c0mb00244e

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