Identifying rare variants associated with hypertension using the C-alpha test

@inproceedings{Faino2014IdentifyingRV,
  title={Identifying rare variants associated with hypertension using the C-alpha test},
  author={Anna V. Faino and Amber Powell and Andr{\'e} A A Williams and Lori J. Silveira},
  booktitle={BMC proceedings},
  year={2014}
}
Important rare variants may be near significantly associated common variants based on genetic distance. For this reason, we conducted an analysis of rare variants informed by tests of single-marker association at loci with common variants. We identified highly significant common variants within chromosome 3, as well as rare variants around these locations. Based on a predetermined window size, we then analyzed these rare variants with the C-alpha test to determine significant associations with… CONTINUE READING