Identifying peroxidases and their oxidants in the early pathology of cystic fibrosis.

  title={Identifying peroxidases and their oxidants in the early pathology of cystic fibrosis.},
  author={Eline Thomson and Siobhain Brennan and Revathy Senthilmohan and Catherine L. Gangell and Anna L. P. Chapman and Peter D. Sly and Anthony J Kettle and Elizabeth Balding and Luke J. Berry and John B Carlin and Rosemary Carzino and Nick H de Klerk and Tonia A Douglas and Clara Jaemie Foo and Luke W Garratt and Graham L Hall and Joanne Harrison and Anthony Kicic and Ingrid Alisa Laing and Karla M. Logie and John Massie and Lauren Sarah Mott and Conor P J Murray and Faith Parsons and Naveen Pillarisetti and Srinivas Reddy Poreddy and Sarath Ranganathan and Colin Francis Robertson and Roy M Robins-Browne and Philip J. Robinson and Billy Skoric and Stephen M Stick and Erika N. Sutanto and Elizabeth R Williamson},
  journal={Free radical biology & medicine},
  volume={49 9},
We aimed to determine whether myeloperoxidase (MPO) is the main peroxidase present in the airways of children with cystic fibrosis (CF) and to assess which oxidants it produces and whether they are associated with clinical features of CF. Children with CF (n=54) and without CF (n=16) underwent bronchoscopy and bronchoalveolar lavage (BAL) for assessment of pulmonary infection and inflammation. BAL fluid was analyzed for MPO, halogenated tyrosines as markers of hypohalous acids, thiocyanate, and… CONTINUE READING


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