Identifying network motifs that buffer front-to-back signaling in polarized neutrophils.


Neutrophil polarity relies on local, mutual inhibition to segregate incompatible signaling circuits to the leading and trailing edges. Mutual inhibition alone should lead to cells having strong fronts and weak backs or vice versa. However, analysis of cell-to-cell variation in human neutrophils revealed that back polarity remains consistent despite changes… (More)
DOI: 10.1016/j.celrep.2013.04.009


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