Identifying natural substrates for chaperonins using a sequence-based approach.

  title={Identifying natural substrates for chaperonins using a sequence-based approach.},
  author={George Stan and Bernard R. Brooks and George H Lorimer and D. Thirumalai},
  journal={Protein science : a publication of the Protein Society},
  volume={14 1},
The Escherichia coli chaperonin machinery, GroEL, assists the folding of a number of proteins. We describe a sequence-based approach to identify the natural substrate proteins (SPs) for GroEL. Our method is based on the hypothesis that natural SPs are those that contain patterns of residues similar to those found in either GroES mobile loop and/or strongly binding peptide in complex with GroEL. The method is validated by comparing the predicted results with experimentally determined natural SPs… CONTINUE READING

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