Identifying key components of the PrPC-PrPSc replicative interface.

  title={Identifying key components of the PrPC-PrPSc replicative interface.},
  author={Gil C Abalos and Justin T. Cruite and Anne Bellon and Saskia Hemmers and Junya Akagi and James A. Mastrianni and Richard A. Williamson and Laura Solforosi},
  journal={The Journal of biological chemistry},
  volume={283 49},
In prion disease, direct interaction between the cellular prion protein (PrP(C)) and its misfolded disease-associated conformer PrP(Sc) is a crucial, although poorly understood step promoting the formation of nascent PrP(Sc) and prion infectivity. Recently, we hypothesized that three regions of PrP (corresponding to amino acid residues 23-33, 98-110, and 136-158) interacting specifically and robustly with PrP(Sc), likely represent peptidic components of one flank of the prion replicative… CONTINUE READING

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Key Components of the PrP-PrP

  • S. K. DebBurman, G. J. Raymond, B. Caughey, S. Lindquist
  • Replicative Interface DECEMBER
  • 1997
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