Identifying hypoxic tissue after acute ischemic stroke using PET and 18F-fluoromisonidazole

@article{Read1998IdentifyingHT,
  title={Identifying hypoxic tissue after acute ischemic stroke using PET and 18F-fluoromisonidazole},
  author={Stephen J Read and T. Hirano and David F. Abbott and J. I. Sachinidis and Henri Jacques Tochon-Danguy and J. Gordon Chan and Gary F. Egan and Andrew Mark Scott and Christopher F Bladin and W. J. Mckay and Geoffrey Alan Donnan},
  journal={Neurology},
  year={1998},
  volume={51},
  pages={1617 - 1621}
}
Objective: To show that PET with 18F-fluoromisonidazole (18F-FMISO) can detect peri-infarct hypoxic tissue in patients after ischemic stroke. Background: PET with 15O-labeled oxygen and water is the only established method for identifying the ischemic penumbra in humans. We used PET with 18F-FMISO in patients after ischemic stroke to identify hypoxic but viable peri-infarct tissue likely to represent the ischemic penumbra, and to determine how long hypoxic tissues persist after stroke. Methods… 

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