Identifying functional domains within terpene cyclases using a domain-swapping strategy.

  title={Identifying functional domains within terpene cyclases using a domain-swapping strategy.},
  author={Kyoungwhan Back and Joe Chappell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 13},
Cyclic terpenes and terpenoids are found throughout nature. They comprise an especially important class of compounds from plants that mediate plant- environment interactions, and they serve as pharmaceutical agents with antimicrobial and anti-tumor activities. Molecular comparisons of several terpene cyclases, the key enzymes responsible for the multistep cyclization of C10, C15, and C20 allylic diphosphate substrates, have revealed a striking level of sequence similarity and conservation of… CONTINUE READING


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Phytochemistry 31 , 3441 - 3445 . Biochemistry : Back and Chappell

  • M. N. Zook, J. Chappell, J. A. Kuc
  • 1992

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