Identifying dysfunctional miRNA-mRNA regulatory modules by inverse activation, cofunction, and high interconnection of target genes: a case study of glioblastoma.

  title={Identifying dysfunctional miRNA-mRNA regulatory modules by inverse activation, cofunction, and high interconnection of target genes: a case study of glioblastoma.},
  author={Yun Xiao and Yanyan Ping and Huihui Fan and Chaohan Xu and Jinxia Guan and Hongying Zhao and Yiqun Li and Yanling Lv and Yan Jin and Lihua Wang and Xia Li},
  volume={15 7},
BACKGROUND Accumulating evidence demonstrates that complex diseases may arise from cooperative effects of multiple dysfunctional miRNAs. Thus, identifying abnormal functions cooperatively regulated by multiple miRNAs is useful for understanding the pathogenesis of complex diseases. METHODS In this study, we proposed a multistep method to identify dysfunctional miRNA-mRNA regulatory modules (dMiMRMs) in a specific disease, in which a group of miRNAs cooperatively regulate a group of target… 

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