Identifying dose dependences of the two-stage clonal expansion model with simulated cohorts.

Abstract

The two-stage clonal expansion model of cancer induction is tested on recorded and simulated cohort data of radon-exposed rats. Unfortunately, different versions of the model, for which radiation acts on different biological processes, can provide a good description of the data. This is the case for an initiation-transformation and an initiation-promotion… (More)

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