Identifying distantly related protein sequences

  title={Identifying distantly related protein sequences},
  author={William R. Pearson},
  journal={Computer applications in the biosciences : CABIOS},
  volume={13 4},
The most powerful method available today for inferring the biological function of a gene (or the protein that it encodes) from its sequence is similarity searching on protein and DNA sequence databases. With the development of rapid methods for sequence comparison, both with heuristic algorithms and powerful parallel computers, discoveries based solely on sequence homology have become routine. Indeed, the vast majority of the gene identifications in the recent descriptions of the Haemophilus… CONTINUE READING
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