Identifying distantly related protein sequences

@article{Pearson1997IdentifyingDR,
  title={Identifying distantly related protein sequences},
  author={William R. Pearson},
  journal={Computer applications in the biosciences : CABIOS},
  year={1997},
  volume={13 4},
  pages={325-32}
}
The most powerful method available today for inferring the biological function of a gene (or the protein that it encodes) from its sequence is similarity searching on protein and DNA sequence databases. With the development of rapid methods for sequence comparison, both with heuristic algorithms and powerful parallel computers, discoveries based solely on sequence homology have become routine. Indeed, the vast majority of the gene identifications in the recent descriptions of the Haemophilus… CONTINUE READING
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References

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Complete genome sequence of the methanogenic archaeon , Methanococcus jannaschii

  • F. Doolittle.R.
  • Science
  • 1996

Effective protein sequence comparison

  • R. W.R.PearsonPearson.W.
  • Methods Enzymoi
  • 1996

Comparison of methods for searching protein sequence databases

  • W. R. Pearson
  • Protein Sci .
  • 1995
1 Excerpt

ClustalW : Improving the sensitivity of progressive multiple alignmenl through sequence weighting , positionspecific gap penalties and weight matrix choice

  • D. Thompson.J., G. Higgins.D., J. Gibson.T.
  • Nucleic Acids Res
  • 1994

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