Identifying differentially expressed genes using false discovery rate controlling procedures

@article{Reiner2003IdentifyingDE,
  title={Identifying differentially expressed genes using false discovery rate controlling procedures},
  author={Anat Reiner and Daniel Yekutieli and Yoav Benjamini},
  journal={Bioinformatics},
  year={2003},
  volume={19 3},
  pages={368-75}
}
MOTIVATION DNA microarrays have recently been used for the purpose of monitoring expression levels of thousands of genes simultaneously and identifying those genes that are differentially expressed. The probability that a false identification (type I error) is committed can increase sharply when the number of tested genes gets large. Correlation between the test statistics attributed to gene co-regulation and dependency in the measurement errors of the gene expression levels further complicates… CONTINUE READING
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