Identifying critical transitions and their leading biomolecular networks in complex diseases

@inproceedings{Liu2012IdentifyingCT,
  title={Identifying critical transitions and their leading biomolecular networks in complex diseases},
  author={Rui Liu and Meiyi Li and Zhi-Ping Liu and Jiarui Wu and Luonan Chen and Kazuyuki Aihara},
  booktitle={Scientific reports},
  year={2012}
}
Identifying a critical transition and its leading biomolecular network during the initiation and progression of a complex disease is a challenging task, but holds the key to early diagnosis and further elucidation of the essential mechanisms of disease deterioration at the network level. In this study, we developed a novel computational method for identifying early-warning signals of the critical transition and its leading network during a disease progression, based on high-throughput data… CONTINUE READING
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