Identifying critical transitions and their leading biomolecular networks in complex diseases

  title={Identifying critical transitions and their leading biomolecular networks in complex diseases},
  author={Rui Liu and Meiyi Li and Zhi-Ping Liu and Jiarui Wu and Luonan Chen and Kazuyuki Aihara},
  booktitle={Scientific reports},
Identifying a critical transition and its leading biomolecular network during the initiation and progression of a complex disease is a challenging task, but holds the key to early diagnosis and further elucidation of the essential mechanisms of disease deterioration at the network level. In this study, we developed a novel computational method for identifying early-warning signals of the critical transition and its leading network during a disease progression, based on high-throughput data… CONTINUE READING
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Showing 1-10 of 38 references

Genomic analysis of murine pulmonary tissue following carbonyl chloride inhalation

  • Sciuto, A.M
  • Chem. Res. Toxicol
  • 2005
Highly Influential
6 Excerpts

Modeling Biomolecular Networks in Cells: Structures and Dynamics, (Springer

  • L. Chen, R. Wang, C. Li, K. Aihara
  • New York,
  • 2010
2 Excerpts

Biomolecular Networks: Methods and Applications in Systems Biology

  • L. Chen, R. Wang, X. Zhang
  • 2009

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