Identifying core gene modules in glioblastoma based on multilayer factor-mediated dysfunctional regulatory networks through integrating multi-dimensional genomic data

@inproceedings{Ping2015IdentifyingCG,
  title={Identifying core gene modules in glioblastoma based on multilayer factor-mediated dysfunctional regulatory networks through integrating multi-dimensional genomic data},
  author={Yanyan Ping and Yulan Deng and Li Wang and Hongyi Zhang and Yong Zhang and Chaohan Xu and Hongying Zhao and Huihui Fan and Fulong Yu and Yun Xiao and Xia Li},
  booktitle={Nucleic acids research},
  year={2015}
}
The driver genetic aberrations collectively regulate core cellular processes underlying cancer development. However, identifying the modules of driver genetic alterations and characterizing their functional mechanisms are still major challenges for cancer studies. Here, we developed an integrative multi-omics method CMDD to identify the driver modules and their affecting dysregulated genes through characterizing genetic alteration-induced dysregulated networks. Applied to glioblastoma (GBM… CONTINUE READING
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