Identifying conformational changes of the beta2 adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators

@article{Reynolds2009IdentifyingCC,
  title={Identifying conformational changes of the beta2 adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators},
  author={Kimberly A. Reynolds and Vsevolod Katritch and Ruben Abagyan},
  journal={Journal of computer-aided molecular design},
  year={2009},
  volume={23 5},
  pages={273-88}
}
The new beta(2) Adrenoceptor (beta(2)AR) crystal structures provide a high-resolution snapshot of receptor interactions with two particular partial inverse agonists, (-)-carazolol and timolol. However, both experimental and computational studies of GPCR structure are significantly complicated by the existence of multiple conformational states coupled to ligand type and receptor activity. Agonists and antagonists induce or stabilize distinct changes in receptor structure that mediate a range of… CONTINUE READING
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Trends in Pharmacological Sciences 2007;28:397

  • BK Kobilka, X. Deupi
  • J Comput Aided Mol Des. Author manuscript…
  • 2009

Bioorganic & Medicinal Chemistry Letters 2008;18:1598

  • S Topiol, M. Sabio
  • 2008
1 Excerpt

Proteins: Structure, Function, and Bioinformatics 2008;71:599

  • C de Graaf, N Foata, O Engkvist, D. Rognan
  • 2008
1 Excerpt

Structure 2008;16:897

  • MA Hanson, V Cherezov, +6 authors RC. Stevens
  • 2008
2 Excerpts

Proteins: Structure, Function, and Bioinformatics. 2007Epub ahead of print. NA

  • SR Kimura, AJ Tebben, DR. Langley
  • 2007

Annual Review of Pharmacology and Toxicology 2006;46:481

  • TW Schwartz, TM Frimurer, B Holst, MM Rosenkilde, CE. Elling
  • 2006

Journal of Computer-Aided Molecular Design 2006;20:463

  • SR Krystek, SR Kimura, AJ Tebben, DR. Langley
  • 2006

Proteins: Structure, Function, and Bioinformatics 2006;64:673

  • EL Mehler, SA Hassan, S Kortagere, H. Weinstein
  • 2006
1 Excerpt

Proteins: Structure, Function, and Bioinformatics 2006;65:824

  • A Patny, PV Desai, MA. Avery
  • 2006

Proteins: Structure, Function, and Bioinformatics 2005;61:938

  • C Bissantz, CS Wolfgang, GM. Stahl
  • 2005

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