Identifying clinically relevant drug resistance genes in drug-induced resistant cancer cell lines and post- chemotherapy tissues

@inproceedings{Tong2015IdentifyingCR,
  title={Identifying clinically relevant drug resistance genes in drug-induced resistant cancer cell lines and post- chemotherapy tissues},
  author={Mengsha Tong and Weicheng Zheng and Xingrong Lu and Lu Ao and Xiangyu Li and Qingzhou Guan and Hao Cai and Mengyao Li and Haidan Yan and You Fu Guo and Pan Chi and Zheng Guo},
  booktitle={Oncotarget},
  year={2015}
}
Until recently, few molecular signatures of drug resistance identified in drug-induced resistant cancer cell models can be translated into clinical practice. Here, we defined differentially expressed genes (DEGs) between pre-chemotherapy colorectal cancer (CRC) tissue samples of non-responders and responders for 5-fluorouracil and oxaliplatin-based therapy as clinically relevant drug resistance genes (CRG5-FU/L-OHP). Taking CRG5-FU/L-OHP as reference, we evaluated the clinical relevance of… CONTINUE READING

Figures, Tables, and Topics from this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 59 REFERENCES