Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models.

@article{Tennant1995IdentifyingCC,
  title={Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models.},
  author={Raymond W. Tennant and John E. French and J. W. Spalding},
  journal={Environmental Health Perspectives},
  year={1995},
  volume={103},
  pages={942 - 950}
}
Cancer is a worldwide public health concern. Identifying carcinogens and limiting their exposure is one approach to the problem of reducing risk. Currently, epidemiology and rodent bioassays are the means by which putative human carcinogens are identified. Both methods have intrinsic limitations: they are slow and expensive processes with many uncertainties. The development of methods to modify specific genes in the mammalian genome has provided promising new tools for identifying carcinogens… CONTINUE READING

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