Identifying causal networks linking cancer processes and anti-tumor immunity using Bayesian network inference and metagene constructs.

@article{Kaiser2016IdentifyingCN,
  title={Identifying causal networks linking cancer processes and anti-tumor immunity using Bayesian network inference and metagene constructs.},
  author={Jacob L Kaiser and Cassidy L Bland and David J. Klinke},
  journal={Biotechnology progress},
  year={2016},
  volume={32 2},
  pages={470-9}
}
Cancer arises from a deregulation of both intracellular and intercellular networks that maintain system homeostasis. Identifying the architecture of these networks and how they are changed in cancer is a pre-requisite for designing drugs to restore homeostasis. Since intercellular networks only appear in intact systems, it is difficult to identify how these networks become altered in human cancer using many of the common experimental models. To overcome this, we used the diversity in normal and… CONTINUE READING
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