Identifying breast cancer patients at risk for Central Nervous System (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG).

@article{Pestalozzi2006IdentifyingBC,
  title={Identifying breast cancer patients at risk for Central Nervous System (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG).},
  author={Bernhard Cornelius Pestalozzi and David Zahrieh and Karen N. Price and Stig B. Holmberg and Jurij Lindtner and Jemima Collins and Diana Crivellari and Martin F. Fey and Elisabeth Murray and Olivia Pagani and E. Simoncini and Monica Castiglione-Gertsch and Richard D. Gelber and Alan S. Coates and Aron Goldhirsch},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2006},
  volume={17 6},
  pages={935-44}
}
BACKGROUND We sought to determine whether a high-risk group could be defined among patients with operable breast cancer in whom a search of occult central nervous system (CNS) metastases was justified. PATIENTS AND METHODS We evaluated data from 9524 women with early breast cancer (42% node-negative) who were randomized in International Breast Cancer Study Group clinical trials between 1978 and 1999, and treated without anthracyclines, taxanes, or trastuzumab. We identified patients whose… CONTINUE READING

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