Identifying association model for single-nucleotide polymorphisms of ORAI1 gene for breast cancer

@inproceedings{Chang2013IdentifyingAM,
  title={Identifying association model for single-nucleotide polymorphisms of ORAI1 gene for breast cancer},
  author={Wei-Chiao Chang and Yong-Yuan Fang and Hsueh-Wei Chang and Li-Yeh Chuang and Yu-Da Lin and Ming-Feng Hou and Cheng-Hong Yang},
  booktitle={Cancer Cell International},
  year={2013}
}
ORAI1 channels play an important role for breast cancer progression and metastasis. Previous studies indicated the strong correlation between breast cancer and individual single nucleotide polymorphisms (SNPs) of ORAI1 gene. However, the possible SNP-SNP interaction of ORAI1 gene was not investigated. To develop the complex analyses of SNP-SNP interaction, we propose a genetic algorithm (GA) to detect the model of breast cancer association between five SNPs (rs12320939, rs12313273, rs7135617… CONTINUE READING
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