Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα.

@article{Swan2013IdentifyingAT,
  title={Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα.},
  author={Caroline Swan and Nathalie P. Duroudier and Eugene Campbell and Abed Zaitoun and Margaret Hastings and George E. Dukes and Joanne Cox and Fiona M Kelly and Jonathan Wilde and Mark G. Lennon and Keith R. Neal and Peter J Whorwell and Ian P Hall and Robin C Spiller},
  journal={Gut},
  year={2013},
  volume={62 7},
  pages={985-94}
}
OBJECTIVES The postinfectious irritable bowel syndrome (PI-IBS) suggests that impaired resolution of inflammation could cause IBS symptoms. The authors hypothesised that polymorphisms in genes whose expression were altered by gastroenteritis might be linked to IBS with diarrhoea (IBS-D) which closely resembles PI-IBS. DESIGN Part 1: 25 healthy volunteers (HVs), 21 patients 6 months after Campylobacter jejuni infection, 37 IBS-D and 19 IBS with constipation (IBS-C) underwent rectal biopsy for… CONTINUE READING