Identifying a species-specific region of yeast TF11B in vivo.

@article{Shaw1996IdentifyingAS,
  title={Identifying a species-specific region of yeast TF11B in vivo.},
  author={Sandra Pride Shaw and John Harvey Wingfield and Michael J. Dorsey and Ji Kai Ma},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 7},
  pages={
          3651-7
        }
}
The general transcription factor IIB (TFIIB) is required for RNA polymerase II transcription in eukaryotes. It provides a physical link between the TATA-binding protein (TBP) and the RNA polymerase and is a component previously suggested to respond to transcriptional activators in vitro. In this report, we compare the yeast (Saccharomyces cerevisiae) and human forms of the protein in yeast cells to study their functional differences. We demonstrate that human TFIIB fails to functionally replace… CONTINUE READING

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