Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3.

@article{Levy2006IdentifyingAC,
  title={Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3.},
  author={Carmit Levy and Yu-Nee Lee and Hovav Nechushtan and Ora Schueler-Furman and Amir Sonnenblick and Shelley Hacohen and Ehud Razin},
  journal={Blood},
  year={2006},
  volume={107 7},
  pages={2839-45}
}
Protein inhibitor of activated STAT3 (PIAS3) functions in vivo as a key molecule in suppressing the transcriptional activity of both microphthalmia transcription factor (MITF) and signal transducer and activator of transcription 3 (STAT3), 2 transcription factors that play a major role in the regulation of growth and function in mast cells and melanocytes. Previously, we have demonstrated binding of PIAS3 to MITF leading to the inhibition of MITF transcriptional activity. Following cellular… CONTINUE READING