Identifying Statistical Dependence in Genomic Sequences via Mutual Information Estimates

  title={Identifying Statistical Dependence in Genomic Sequences via Mutual Information Estimates},
  author={Hasan Metin Aktulga and Ioannis Kontoyiannis and Leszek Alex Lyznik and Lukasz Szpankowski and Ananth Grama and Wojciech Szpankowski},
  booktitle={EURASIP J. Bioinformatics and Systems Biology},
Questions of understanding and quantifying the representation and amount of information in organisms have become a central part of biological research, as they potentially hold the key to fundamental advances. In this paper, we demonstrate the use of information-theoretic tools for the task of identifying segments of biomolecules (DNA or RNA) that are statistically correlated. We develop a precise and reliable methodology, based on the notion of mutual information, for finding and extracting… CONTINUE READING
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