Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins

@article{Lam2020IdentifyingSC,
  title={Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins},
  author={Tommy Tsan-Yuk Lam and Na Jia and Ya-Wei Zhang and Marcus Ho-Hin Shum and Jia-Fu Jiang and Hua Chen Zhu and Yi-Gang Tong and Yong-xia Shi and Xue-bing Ni and Yunshi Liao and Wen-juan Li and Bao-Gui Jiang and Wei Wei and Tingting Yuan and Kui Zheng and Xiao-Ming Cui and Jie Li and Guangqian Pei and Xin Qiang and William Yiu-Man Cheung and Lianfeng Li and Fang-Fang Sun and Si Qin and Ji-cheng Huang and G. Leung and Edward C. Holmes and Yanling Hu and Yi Guan and Wu-Chun Cao},
  journal={Nature},
  year={2020},
  volume={583},
  pages={282-285}
}
The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-2 1 . This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection 2 . Although bats are probable reservoir hosts for SARS-CoV-2, the identity of any intermediate host that may have facilitated transfer to humans is unknown. Here we report the identification of SARS-CoV-2-related… Expand

Paper Mentions

Observational Clinical Trial
The Respiratory infection COVID-19, due to a new coronavirus, SARS-CoV2, appeared in December 2019 in several people who attended the wildlife market in Wuhan, Hubei Province, China… Expand
ConditionsCovid19, Influenza -Like Illness
InterventionDiagnostic Test
Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins
TLDR
It is shown that a coronavirus isolated from a Malayan pangolin has 100%, 98.6%, 97.8% and 90.7% amino acid identity with SARS-CoV-2 in the E, M, N and S proteins, respectively, which suggests that the latter may have originated from a recombination event involving Sars-related coronaviruses from bats and pangolins. Expand
Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia
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The identification of SARS-CoV-2 related coronaviruses in two Rhinolophus shameli bats sampled in Cambodia in 2010 is described and suggests that Southeast Asia represents a key area to consider in the ongoing search for the origins of Sars-Cov-2, and in future surveillance for coronavIRuses. Expand
Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak
Summary An outbreak of coronavirus disease 2019 (COVID-19) caused by the 2019 novel coronavirus (SARS-CoV-2) began in the city of Wuhan in China and has widely spread worldwide. Currently, it isExpand
Identification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor
  • Hua Guo, Ben Hu, +9 authors Zheng-Li Shi
  • Medicine
  • Emerging microbes & infections
  • 2021
TLDR
This study identified a novel lineage of SARSr-CoVs, including RaTG15 and seven other viruses, from bats at the same location where the authors found RaTG13 in 2015 and found that the Ra TG15 receptor-binding domain (RBD) can bind to ACE2 from Rhinolophus affinis, Malayan pangolin, and use it as an entry receptor, except forACE2 from humans. Expand
Identification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor
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RaTG15 receptor binding domain (RBD) can bind to and use Rhinolophus affinis bat ACE2 but not human ACE2 as entry receptor, although which contains a short deletion and has different key residues responsible for ACE2 binding. Expand
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Molecular evolution and phylogenetic analysis of SARS-CoV-2 and hosts ACE2 protein suggest Malayan pangolin as intermediary host
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An evolutionary analysis combining viral and host phylogenies and divergence of ACE2 and TMPRSS2 amino acid sequences between CoV hosts finds pangolin has become an opportune host to intermediates bat-to-human SARS-CoV-2 jump and entry. Expand
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The phylogeny of SARS-CoV-2 is described, covering various related studies, in particular, focusing on viruses obtained from horseshoe bats and pangolins that belong to Sarbecovirus, a subgenus of Betacoronavirus. Expand
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