Identifying RNA-binding residues based on evolutionary conserved structural and energetic features

@inproceedings{Chen2014IdentifyingRR,
  title={Identifying RNA-binding residues based on evolutionary conserved structural and energetic features},
  author={Yao Chi Chen and Karen Sargsyan and Jon D. Wright and Yi-Shuian Huang and Carmay Lim},
  booktitle={Nucleic acids research},
  year={2014}
}
Increasing numbers of protein structures are solved each year, but many of these structures belong to proteins whose sequences are homologous to sequences in the Protein Data Bank. Nevertheless, the structures of homologous proteins belonging to the same family contain useful information because functionally important residues are expected to preserve physico-chemical, structural and energetic features. This information forms the basis of our method, which detects RNA-binding residues of a… CONTINUE READING