Identifying RNA-binding residues based on evolutionary conserved structural and energetic features

@article{Chen2014IdentifyingRR,
  title={Identifying RNA-binding residues based on evolutionary conserved structural and energetic features},
  author={Y. Chen and K. Sargsyan and J. Wright and Yi-Shuian Huang and C. Lim},
  journal={Nucleic Acids Research},
  year={2014},
  volume={42},
  pages={e15 - e15}
}
  • Y. Chen, K. Sargsyan, +2 authors C. Lim
  • Published 2014
  • Medicine, Biology
  • Nucleic Acids Research
  • Increasing numbers of protein structures are solved each year, but many of these structures belong to proteins whose sequences are homologous to sequences in the Protein Data Bank. Nevertheless, the structures of homologous proteins belonging to the same family contain useful information because functionally important residues are expected to preserve physico-chemical, structural and energetic features. This information forms the basis of our method, which detects RNA-binding residues of a… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 57 REFERENCES
    The Calculi of Lambda Conversion
    • 1985
    Further development and validation of empirical scoring functions for structure-based binding affinity prediction
    821
    Strategic Intent for IT Outsourcing
    • Anthony DiRomualdo, Vijay Gurbaxani
    • Business
    • 1998
    552
    An investigation of solanine poisoning
    27
    BindN+ for accurate prediction of DNA and RNA-binding residues from protein sequence features
    175