Identifying Protein Binding Hot Spots by Using Deeply Buried Atomic Contacts

Abstract

Solvent accessible surface area (SASA) is an important descriptor of protein residues and atoms. It is widely used as an outstanding feature in hot spot prediction by many computational methods. However, SASA is not capable of distinguishing slightly buried residues, of which most are non hot spots, and deeply buried ones that are usually inside a hot spot… (More)

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