Identifying Novel Type ZBGs and Nonhydroxamate HDAC Inhibitors Through a SVM Based Virtual Screening Approach.

@article{Liu2010IdentifyingNT,
  title={Identifying Novel Type ZBGs and Nonhydroxamate HDAC Inhibitors Through a SVM Based Virtual Screening Approach.},
  author={Xianghui Liu and Hong Yan Song and Jingxian Zhang and Bo Chong Han and X. N. Wei and Xiaohua Ma and Wanli Cui and Yu Zong Chen},
  journal={Molecular informatics},
  year={2010},
  volume={29 5},
  pages={407-20}
}
Histone deacetylase inhibitors (HDACi) have been successfully used for the treatment of cancers and other diseases. Search for novel type ZBGs and development of non-hydroxamate HDACi has become a focus in current research. To complement this, it is desirable to explore a virtual screening (VS) tool capable of identifying different types of potential inhibitors from large compound libraries with high yields and low false-hit rates similar to HTS. This work explored the use of support vector… CONTINUE READING