Identifying New Therapeutic Targets via Modulation of Protein Corona Formation by Engineered Nanoparticles

@inproceedings{Arvizo2012IdentifyingNT,
  title={Identifying New Therapeutic Targets via Modulation of Protein Corona Formation by Engineered Nanoparticles},
  author={Rochelle R. Arvizo and Karuna Giri and Daniel F. Moyano and Oscar R. Miranda and Benjamin Madden and Daniel J. Mccormick and Resham Bhattacharya and Vincent M Rotello and Jean-Pierre A. Kocher and Priyabrata Mukherjee},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND We introduce a promising methodology to identify new therapeutic targets in cancer. Proteins bind to nanoparticles to form a protein corona. We modulate this corona by using surface-engineered nanoparticles, and identify protein composition to provide insight into disease development. METHODS/PRINCIPAL FINDINGS Using a family of structurally homologous nanoparticles we have investigated the changes in the protein corona around surface-functionalized gold nanoparticles (AuNPs) from… CONTINUE READING