Identifying Neighborhoods of Coordinated Gene Expression and Metabolite Profiles

  title={Identifying Neighborhoods of Coordinated Gene Expression and Metabolite Profiles},
  author={Timothy Hancock and Nicolas Wicker and Ichigaku Takigawa and Hiroshi Mamitsuka},
  booktitle={PloS one},
In this paper we investigate how metabolic network structure affects any coordination between transcript and metabolite profiles. To achieve this goal we conduct two complementary analyses focused on the metabolic response to stress. First, we investigate the general size of any relationship between metabolic network gene expression and metabolite profiles. We find that strongly correlated transcript-metabolite profiles are sustained over surprisingly long network distances away from any target… CONTINUE READING

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