Identifying Mechanisms of Homeostatic Signaling in Fibroblast Differentiation

@article{Warsinske2015IdentifyingMO,
  title={Identifying Mechanisms of Homeostatic Signaling in Fibroblast Differentiation},
  author={H. Warsinske and Shanna L. Ashley and J. Linderman and B. Moore and D. Kirschner},
  journal={Bulletin of Mathematical Biology},
  year={2015},
  volume={77},
  pages={1556-1582}
}
  • H. Warsinske, Shanna L. Ashley, +2 authors D. Kirschner
  • Published 2015
  • Mathematics, Medicine
  • Bulletin of Mathematical Biology
  • Fibroblasts play an important role in the wound-healing process by generating extracellular matrix (ECM) and undergoing differentiation into myofibroblasts, but these cells can also be involved in pathologic remodeling of tissue. Nascent ECM provides a substrate for re-epithelialization to occur, restoring damaged tissue to a functional state. Dysregulation of this process can result in fibrosis—stiffening and scarring of the tissue. Current treatments cannot halt or reverse this process. The… CONTINUE READING
    A novel chemo-mechano-biological model of arterial tissue growth and remodelling.
    • 21
    • Highly Influenced
    • PDF
    Inducing chondrogenesis in MSC/chondrocyte co-cultures using exogenous TGF-β: a mathematical model.
    • 8
    • PDF
    Inducing chondrogenesis in MSC/chondrocyte co-cultures using exogenous TGF-β: a mathematical model
    • 1
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 79 REFERENCES
    Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
    • 2,518
    • PDF
    Tissue Cells Feel and Respond to the Stiffness of Their Substrate
    • 4,727
    • PDF
    Myofibroblast Differentiation by Transforming Growth Factor-β1 Is Dependent on Cell Adhesion and Integrin Signaling via Focal Adhesion Kinase*
    • 498
    • Highly Influential
    • PDF
    Dynamics of Transforming Growth Factor Beta Signaling in Wound Healing and Scarring.
    • 148
    Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction.
    • 282
    • Highly Influential
    • PDF
    Smad-dependent and Smad-independent pathways in TGF-β family signalling
    • 3,628
    • PDF
    Factors Affecting Wound Healing
    • 2,197
    • PDF