Identifying Mechanisms of Homeostatic Signaling in Fibroblast Differentiation.

  title={Identifying Mechanisms of Homeostatic Signaling in Fibroblast Differentiation.},
  author={Hayley C. Warsinske and Shanna L. Ashley and Jennifer J. Linderman and Bethany B Moore and Denise E. Kirschner},
  journal={Bulletin of mathematical biology},
  volume={77 8},
Fibroblasts play an important role in the wound-healing process by generating extracellular matrix (ECM) and undergoing differentiation into myofibroblasts, but these cells can also be involved in pathologic remodeling of tissue. Nascent ECM provides a substrate for re-epithelialization to occur, restoring damaged tissue to a functional state. Dysregulation of this process can result in fibrosis--stiffening and scarring of the tissue. Current treatments cannot halt or reverse this process. The… CONTINUE READING


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