Identifying Master Regulators of Cancer and Their Downstream Targets by Integrating Genomic and Epigenomic Features

@article{Gevaert2013IdentifyingMR,
  title={Identifying Master Regulators of Cancer and Their Downstream Targets by Integrating Genomic and Epigenomic Features},
  author={Olivier Gevaert and Sylvia K. Plevritis},
  journal={Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing},
  year={2013},
  pages={123-34}
}
Vast amounts of molecular data characterizing the genome, epigenome and transcriptome are becoming available for a variety of cancers. The current challenge is to integrate these diverse layers of molecular biology information to create a more comprehensive view of key biological processes underlying cancer. We developed a biocomputational algorithm that integrates copy number, DNA methylation, and gene expression data to study master regulators of cancer and identify their targets. Our… CONTINUE READING

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