Identifying Hfq-binding small RNA targets in Escherichia coli.

  title={Identifying Hfq-binding small RNA targets in Escherichia coli.},
  author={Yong Zhang and Shiwei Sun and Tao Wu and Jie Wang and Changning Liu and Lan Chen and Xiaopeng Zhu and Yi Zhao and Zhihua Zhang and Baochen Shi and Hongchao Lu and Runsheng Chen},
  journal={Biochemical and biophysical research communications},
  volume={343 3},
The Hfq-binding small RNAs (sRNAs) have recently drawn much attention as regulators of translation in Escherichia coli. We attempt to identify the targets of this class of sRNAs in genome scale and gain further insight into the complexity of translational regulation induced by Hfq-binding sRNAs. Using a new alignment algorithm, most known negatively regulated targets of Hfq-binding sRNAs were identified. The results also show several interesting aspects of the regulatory function of Hfq-binding… CONTINUE READING

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