Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach

@inproceedings{Edwards2011IdentifyingCD,
  title={Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach},
  author={Yvonne J. K. Edwards and Gary W. Beecham and William K. Scott and Sawsan Khuri and G Bademci and Demet Tekin and Eden R. Martin and Zhijie Jiang and Deborah C. Mash and Jarlath ffrench-Mullen and Margaret A. Pericak-Vance and Nicholas F. Tsinoremas and Jeffery M. Vance},
  booktitle={PloS one},
  year={2011}
}
Parkinson's disease (PD) has had six genome-wide association studies (GWAS) conducted as well as several gene expression studies. However, only variants in MAPT and SNCA have been consistently replicated. To improve the utility of these approaches, we applied pathway analyses integrating both GWAS and gene expression. The top 5000 SNPs (p<0.01) from a joint analysis of three existing PD GWAS were identified and each assigned to a gene. For gene expression, rather than the traditional comparison… CONTINUE READING
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